There has been some persistent use of "T, revolutum DC." for this species (e.g. J, Soza et al. 2013), but amphibolum was considered correct by FNA 3 and subsequent authorities (K, W). T. amphibolum is widespread on well-drained base-rich soils across eastern North America, and there are scattered disjunct western records (K). However, it appears to be a somewhat conservative remnant of grassy openings, and does not generally spread into modern landscapes. In Ky. some Appalachian records may be doubted; see also note under coriaceum. There has been much confusion with pubescens and dasycarpum across its range, and molecular analysis indicates that these three taxa are intimately related in a strictly dioecious North American clade (Soza et al. 2012, 2013). T. amphibolum is best distinguished by its moderately long anthers (usually 1.2-2.7 mm) and stigmas (1.5-3.5 mm). It flowers earlier (usually late Apr-Jun versus late May-Jul). Its leaflets tend to be more elongated (L/W = 0.9-5.25 versus 0.9-2.6), more revolute and more skunky-smelling. Occasional plants of amphibolum can lack its usually distinctive glandular hairs (especially in shade), but it never has simple eglandular hairs (FNA 3, W). Reportedly, 2n = ca, 134 (Cr) or 140 (Soza et al. 2013).The genus Thalictrum, globally is known to produce diverse alkaloids and other compounds with physiological activity in mammals, with medicinal applications (Kuzmanov & Dutschewska 1982, Singh et al. 2023). However, there has been rather little published information on the chemistry of North American species, for example Wu et al. (1980) regarding "revolutum".