In morphology, ecology and range, this widespread species of east-central states is similar to reniforme; but 2n = 50, 52 and 56 (versus just 50). It is generally more common throughout central and southern Appalachian regions to the mid-west. It typically occurs on drier or less fertile soils, and it appears more tolerant of disturbance or even light-demanding. Cr reported hybridization, but there does not appear to be definitive evidence (FNA 20). There has been some medicinal use, which may be related to cytotoxic "oplopane" sesquiterpenoids (Clement et al. 2016).