This common "tobacco" is a tetraploid (2n = 48) from warmer regions of the Americas that became widely cultivated in southeastern states after settlement from Europe. n Ky. it has occasionally been collected for herbaria, but it is not truly naturalized. N. rustica L. ("Aztec Tobacco") was reported by Webb & Funkhauser (1936) from excavations of native american sites in MENI; that species originated in Peru.