This variable northeastern species is centered in Appalachian regions but extends to southern Ala. and Miss. (K); 2n = 84, 126 and 154 (Cr, FNA 3, K; Soza et al.. 2013). In Ky. is widely scattered in low alluvial woods, thickets and edges near streams, but it appears to have largely disappeared from more agricultural regions. Colls. from the Bluegrass region were mostly made before 1950. Typical pubescens can easily be confused wirth dasycarpum, as detailed under that name; see also W. Leaves and fruits of pubescens are finely pubescent, without glands, but dasycarpum usually has some glands. Despite some ancient medicinal uses of this species (Moerman 1986), there has been little recent publication on its chemistry (Gharbo et al. 1973, Kuzmanov & Dutschewska 1982).